Glucocorticoids in pregnancy

Glucocorticoids in pregnancy.

The fetus may be exposed to increased endogenous or synthetic glucocorticoid (GS) exposure in late gestation. Approximately 7% of pregnant women in Europe and North America are treated with synthetic GSs to promote lung maturation in fetuses at risk of preterm delivery. Maternal steroid treatment before preterm delivery is one of the best documented and most cost effective life saving treatment...

Potential significance of physiological and pharmacological glucocorticoids in early pregnancy.

BACKGROUND Despite extensive studies of the developmental consequences of increased glucocorticoid exposure in mid- to late pregnancy, relatively little is known regarding the significance of glucocorticoids in early pregnancy. The objective of this review was to consider potential roles for this family of corticosteroids that might relate to early pregnancy. METHODS Although this is a narrat...

Inhaled glucocorticoids promotes osteoporosis in asthma patients

Background: Recently many studies have focused on the possible role of corticosteroids inhalation on osteoporosis in asthma patients. This study aimed to determine whether the indicatives of bone formation or resorption are different between asthma patients with healthy subjects. Materials and Methods: To achieve this outcome, twenty one middle-aged asthma patients treated with inhaled cortico...

The Role of Glucocorticoids in Pregnancy: Four Decades Experience with Use of Betamethasone in the Prevention of Pregnancy Loss

Are glucocorticoids good indicators of pregnancy constraints in a capital breeder?

Pregnancy imposes a substantial energetic demand on the mother (i.e. metabolic costs of pregnancy) and is often associated with modified maternal behavior and increased physical burdens that make females more vulnerable to predation. The Hypothalamic-Pituitary-Adrenal axis plays a fundamental role in reproduction through hormonal control of energy regulation and parental care. Therefore, evalua...